Salivary miRNAs are predominantly in exosomes.

<p>(<b>a</b>) Absolute differences in microRNA levels amplified from saliva exosome pellet (○) and exosome-depleted supernatant (□). 1 unit increase in CT represent a two-fold lower amount of miRNA. miRNAs requiring 35 cycles or more are considered undetectable. (<b>b</b>) Graph showing the average of three samples in microRNA levels amplified from serum exosome pellet (○) and exosome-depleted supernatant (□) and whole serum (▵). Ct value for the whole serum samples was consistently lower (by at least 2 cycles) than the supernatant and at least 1.5 cycles higher than the exosome pellet samples.