Changes in Cerebral perfusion.

<p>(A) Perfusion weighted imaging was performed in animals receiving MNC or saline at 24 hrs after MCA occlusion. There was a significant decrease (‡p<0.05) in the mean TTP in the peri-infarct region at 5 minutes after MNC infusion via IA or IV routes of delivery. There was no significant change in TTP in the saline group before and after injection. N = 4 per group. (B) Cerebral perfusion (CP) was monitored with Laser Doppler flowmetry over the peri-infarct area of animals administered MNCs (10 million cells) or saline at 24 hrs after MCA occlusion. CP was expressed after injection as a percentage compared with the baseline pre-injection value. CP increased at 5 minutes after MNC injection. There was no significant change in CP in the saline treated group. N = 6 per group. (C): Time course of changes in cerebral perfusion after IV injection of MNCs (10 million cells), FBCs (10 million), or saline. ‡p<0.05 refers to the MNC group compared to the saline group and §p<0.05 refers to the MNC group compared with the FBC group. There was significant elevation of CP after MNC infusion at 1, 3, 5, 10 and 15 minutes. There was no significant change in CP in the saline or FBC groups. ‘0’ on x-axis represents the time in minutes, just before the injection. N = 6 per group.