DCS normalized the reduced GluA1 expression in prefrontal cortex in GluD1 KO.

<p>Synaptoneurosomes were prepared from amygdala and prefrontal cortex 2 hours after the end of the social novelty test in which saline or DCS (320 mg/kg) was administered intraperitoneally (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032969#pone-0032969-g007" target="_blank">Fig. 7</a>) (n = 3 for each group). GluA1 expression was higher in GluD1 KO amygdala and lower in the prefrontal cortex. DCS did not normalize the higher GluA1 expression in amygdala (two-way ANOVA, drug F(1,8) = 0.7175, P = 0.4216; genotype F(1,8) = 35.59, P = 0.0003; interaction F(1,8) = 0.2622, P = 0.6224). In the prefrontal cortex the lower GluA1 expression was increased to the WT levels by DCS treatment (two-way ANOVA, drug F(1,8) = 11.57, P = 0.0093; genotype F(1,8) = 5.884, P = 0.0415; interaction F(1,8) = 6.140, P = 0.0382). Data are presented as mean ± SEM. * represents P<0.05.