Concentrations of conjugated BAs in liver during aging of male and female mice.

<p>(A) Concentrations of individual conjugated BAs in liver during aging and (B) proportions of them in all conjugated BAs in liver at 3 and 27 months of age in male and female mice. Data are presented as means ± SEM of 5–7 mice. Daggers (†) represent statistically significant difference from the value at 3 months of age during aging of male mice. Double daggers (‡) represent significant difference from the value at 3 months of age during aging of female mice. Age-dependent differences were considered at <i>p</i><0.05 by one-way ANOVA, followed by Duncan's post-hoc test. Asterisks (*) represent statistically significant difference between male and female mice at respective ages during aging (<i>p</i><0.05), by student t-test. In panel B, pound signs (#) represent differences of BA proportions between 3 and 27 months.