Light microscopic lesions.

<p>(A) Glomerulus, Dog 11 at T0. Early glomerular lesions including minimal increase of mesangial matrix. Periodic acid-Schiff staining (×400); (B) Glomerulus, Dog 11 at T16 weeks. Moderate hypercellularity of mesangial and endothelial cells and one synechia. There is segmental to global increase of mesangial matrix and Bowman's capsule is symmetrically thickened with proliferation of parietal epithelial cells. Periodic acid-Schiff staining (×400); (C) Glomerulus, Dog 11 at T24 weeks. Moderate hypercellularity of mesangial and endothelial cells associated with global increase of mesangial matrix. Visceral epithelial cells are hypertrophic. Periodic acid-Schiff staining (×400); (D) Tubulo-interstitium, Dog 11 at T24 weeks. Moderate inflammation widely separating tubules and atrophic tubules. Periodic acid-methenamine silver staining (×400).