The distribution histogram of human median inter-chromosomal CS-distances obtained with different permitted maximal levels of GC differences between scored 100 kb segments.

<p>The inter-chromosomal CS-distances obtained without restriction on inter-segmental GC differences contain both compositional and organizational components of inter-chromosomal heterogeneity (thereby coinciding with H_t). The stricter conditions on ΔGC reduce the influence of H_c on the estimate of H_o. All ΔGC thresholds that are ≤0.02 show just slightly different distributions of human inter-chromosomal H_o. Therefore, we believe that ΔGC≤0.02 condition permits us to assess organizational inter-chromosomal heterogeneity without the influence of compositional heterogeneity.