Metastatic derivative in a series of isogenic cell lines exerts greater forces.

<p>(A) Phase images of parental untransformed cells (MCF10A), transformed premalignant (MCF10AT1) and highly metastatic (MCF10CA1a) derivatives. (B) Net traction forces increase with increasing metastatic potential, with the highest forces exerted by the metastatic MCF10CA1a cells. (C) Average traction stress (|<i>F</i>|/A) increases with increasing metastatic potential. Mean ± SEM; ** indicates p<0.01; *** indicates p<0.001.