Association of GAP domain mutations with clinical and pathological parameters associated with aggressive prostate cancer.

<p>The fraction of clones containing missense or stop mutations for cases with each indicated clinical or pathological parameter is shown. All differences between pathological and clinical variables were statistically significant. Specifically: for early PSA recurrence (<2 years post surgery) versus no or late recurrence (p<0.001, chi sq); extracapsular extension (ECE) versus no ECE (p = 0.015, chi sq); seminal vesicle invasion (SVI) versus no SVI (p = 0.027, chi sq); pelvic lymph node metastasis (LN) versus no metastasis (p = 0.027, chi sq); Gleason 5/6 versus 7–10 (p = 0.002, chi sq).