Reduction by argon (Ar) of OGD-induced LDH release.

<p>(<b>A</b>) Concentration-response effects of argon (Ar) on OGD-induced LDH release (n = 23–27 per group). Exposure to OGD led to an increase in LDH release. Argon of 37.5 vol% to 75 vol% significantly reduced the increase in LDH release induced by OGD. (<b>B</b>) Time-course effects of OGD-induced cell injury and argon-induced neuroprotection. Cell injury induced by OGD as well as neuroprotection by argon increased as a function of time during the 3-h “reperfusion” period. Data are expressed as mean ± SEM. <b>*</b><i>P</i><0.05 <i>vs</i> OGD control slices; <b>⁺</b><i>P</i><0.05 <i>vs</i> sham slices.