Degree of insulitis in NOD mice.

<p>Islets obtained from animals injected with MAb 8E6G4 IgG (50 and 100 µg), control IgG, and PBS were scored as normal islets (score 1), perivascular/periductal infiltration (score 2), peri-insulitis (score 3), mild insulitis (<25% of the islet infiltrated; score 4), and severe insulitis (more than 25% of the islet infiltrated, score 5). The mean score for each group was calculated by dividing the total score by the number of islets scored.