Masson's trichrome staining findings for collagen.

<p>(A) Unwounded (normal) skin with regularly arranged, small collagen fibers. (B) In the control group treated with empty liposomes, the amount of collage fibers is far more than that in the normal group, and collage fibers are thicker, denser and disorganized. (C) Contractubex. (D–F) After treatment with (D) 2.5%, (E) 5% and (F) 10% LEO for 28 days, the collagen fibers were arranged more regularly and sparse than those in the control group. Original magnification ×400.