<p>Here the mean and range of each of the datasets from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030435#pone-0030435-g006" target="_blank">Figure 6</a> are plotted, together with the simulation results from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030435#pone-0030435-g007" target="_blank">Figure 7</a>, with the model outputs suitably scaled (the peak of the experimental mean for each of the two immunoglobulins matched by the peak of the full T-dependent system).</p
(A) Histogram of EDs from Group 1 with IGE (blue) and histogram of EDs simulated using the model wit...
<p>(a–c) Defective antigen-specific IgG1 and IgG2b production in response to TD antigens for primary...
<p>Immunoglobulin G (IgG) subclasses were determined in serum collected three weeks after the third ...
<p>All figures present variables on a log scale as percentages of their peak value.</p
Each row represents the peak CD4+ T cell response in a Monte Carlo simulation, where 50 realizations...
<p>The scaled level of -cells at steady state (A1–A4), the total scaled levels of autoreactive auto...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<p>In the simulations for this plot, the affinity of the immunodominant T cell specificity is set to...
<p>Relative frequencies fitting at time point <i>n</i> = 6 (96 hours) post immunization for all the ...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<p>(A,C) Plot of modeled uninfected T-cell population (blue), normal Treg (green) and adaptive Treg ...
<p>(A) Scatter plot of LHS simulation results with respect to the T cell death rate, <i>d<sub>T</sub...
<p>A: Simulation results based on Eq. (1) with and the source term Eq. (5) for different substituti...
<p>Experimental responses of purified IgG against the VB are shown in percent on the x-axis and are ...
<p>(A) CD4+ response rates. (B) CD4+ response magnitude. (C) CD8+ response rate. (D) CD8+ response m...
(A) Histogram of EDs from Group 1 with IGE (blue) and histogram of EDs simulated using the model wit...
<p>(a–c) Defective antigen-specific IgG1 and IgG2b production in response to TD antigens for primary...
<p>Immunoglobulin G (IgG) subclasses were determined in serum collected three weeks after the third ...
<p>All figures present variables on a log scale as percentages of their peak value.</p
Each row represents the peak CD4+ T cell response in a Monte Carlo simulation, where 50 realizations...
<p>The scaled level of -cells at steady state (A1–A4), the total scaled levels of autoreactive auto...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<p>In the simulations for this plot, the affinity of the immunodominant T cell specificity is set to...
<p>Relative frequencies fitting at time point <i>n</i> = 6 (96 hours) post immunization for all the ...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<p>(A,C) Plot of modeled uninfected T-cell population (blue), normal Treg (green) and adaptive Treg ...
<p>(A) Scatter plot of LHS simulation results with respect to the T cell death rate, <i>d<sub>T</sub...
<p>A: Simulation results based on Eq. (1) with and the source term Eq. (5) for different substituti...
<p>Experimental responses of purified IgG against the VB are shown in percent on the x-axis and are ...
<p>(A) CD4+ response rates. (B) CD4+ response magnitude. (C) CD8+ response rate. (D) CD8+ response m...
(A) Histogram of EDs from Group 1 with IGE (blue) and histogram of EDs simulated using the model wit...
<p>(a–c) Defective antigen-specific IgG1 and IgG2b production in response to TD antigens for primary...
<p>Immunoglobulin G (IgG) subclasses were determined in serum collected three weeks after the third ...