IVIg prevents 34-1-2s-induced lung damage in BALB/c and SCID mice.

<p>Wet/Dry ratios in non-treated (−) naïve BALB/c mice (column 1) and treated (+) BALB/c mice (columns 2,3) or SCID mice (columns 4–10) administered the indicated treatments (below left). TRALI was induced with an iv injection of 2 mg/kg 34-1-2s iv for SCID mice and 9 mg/kg 34-1-2s for BALB/c mice. Some mice were treated prophylactically 18 hours before TRALI induction with either 2 g/kg of IVIg (IVIg (2) −18 h), 1 g/kg of IVIg (IVIg (1) −18 h) or a control infusion with 2 g/kg human serum albumin (HSA −18 h) or 1 g/kg IVIg F(ab′)₂ fragments (F(ab′)₂ −18 h). The other mice were treated within 3 minutes after TRALI induction with 1 g/kg of IVIg (IVIg (1) +3 m). Two hours after TRALI induction, the mice were sacrificed and lung wet/dry (W/D) ratios were measured. The data is expressed as the individual mouse W/D ratios in each group and means±SEM are also shown. Statistics were performed using a one way ANOVA and the ★ indicates significance (p<0.001) between the indicated comparisons.