Inhibition or negation of Kv7 conductance increases the after-depolarisation.

<p>A) Example voltage trace for theta burst protocol of postsynaptic action potentials. Box illustrates section shown in B and C. B) Negative dynamic clamp Kv7 conductance (blue) increases the after-depolarisation (ADP) measured 20 ms after the last action potential (illustrated by vertical line) in a theta burst compared to control (black). C) XE-991 (10 µM, red) increases the ADP compared to control (black) and this was reversed by introduction of positive dynamic clamp Kv7 conductance (green). D) Average ADP amplitude was increased by negative dynamic clamp Kv7 conductance or XE-991. E) Average action potential (AP) half-width for the first action potential in a theta burst was unchanged by negative dynamic clamp Kv7 conductance or XE-991.