Lung injury in mice challenged intranasally with <i>B. anthracis</i> was reduced by cSN50 treatment.

<p>Lung sections A, C, E, G and H stained with Hematoxylin and Eosin (HE). B, D, and F stained with Periodic Acid-Schiff and Hematoxylin (PAS). A–D. Untreated mice. Marked pulmonary edema (A–B) and hemorrhage (C) throughout. Clumps of bacteria (large arrow) and individual bacteria (small arrow) highlighted by PAS stain (D). E–F. Mice treated with saline+ciprofloxacin. Foci of edema, cellular infiltrates, and hemorrhage (E). Clumps of bacteria (arrow) and scattered individual bacteria visualized with PAS stain (F). G–H. Mice treated with cSN50 peptide+ciprofloxacin. Minimal edema in mice surviving 9 days (G) and essentially normal lungs in mice sacrificed at 21 days (H). PAS stained sections in mice from these groups were negative for bacilli (not shown).