Effect of MFN2 deficiency on oxygen consumption rate (OCR) profile.

<p>(<b>A</b>) Serial measurements of OCR at 7 minute intervals (“measurement number”) in MFN2-deficienct (MFN2-) and control (empty virus transduced <i>“CTL”</i> or non-transduced; <i>“NT”</i>) cells at baseline and after the addition of oligomyin, CCCP, or antimycin. Results of a single representative study with five replicate OCR measurements and their SD is shown. (<b>B</b>) OCR due to baseline ATP turnover rate (<i>baseline minus oligomycin OCR</i>) in each group expressed as the mean and SD of 3 separate experiments; NS “non significant; <i>P</i>>0.05. (<b>C</b>) OCR due to maximal mitochondrial ATP turnover rate (<i>CCCP stimulated minus oligomycin OCR</i>) in each group expressed as the mean and SD of 3 separate experiments; NS “non significant; <i>P</i>>0.05.