GBV-C NS3/4A inhibition of HIV replication in Jurkat cells is dose-dependent.

<p>(<b>A</b>) Jurkat cells were transfected with either 3 µg HIV pNL4-3 (HIV), 3 µg of HIV pNL4-3+3 µg pCDNA3.1/Zeo+ (HIV+vector), or 3 µg HIV pNL4-3+3 µg NS3/4A in pCDNA3.1/Zeo+ (HIV+NS3/4A) (blue line). Mean and standard errors of p24 values in supernatants collected on days 1, 3, and 7 are shown. (<b>B</b>) Jurkat cells were transfected with HIV pNL4-3 and either 6 or 9 µg of NS3/4A expression plasmid (blue lines) or equivalent amounts of CAT expression plasmid; mean and standard errors of p24 values in supernatants collected on days 1, 3, and 6 are shown.