<p>A. Shown are representative images of double immunohistochemistry for P-STAT3 (DAB) and β-Endorphin (green fluorescence) in the mediobasal hypothalamus of leptin-treated LFD and HFD mice. C57Bl/6J mice were given diets for 16 weeks and injected with leptin 30 minutes before sacrifice. B. Percentage of P-STAT3 immunoreactive POMC (β-Endorphin) neurons per hypothalamus. One hemisphere of 9–11 matched hypothalamic brain sections was analyzed in each animal. C. Shown is the total P-STAT3 immunoreactivity (P-STAT3 IR) in all POMC neurons. For B. and C. P-STAT3 was counted and quantified in 258±24 POMC neurons from LFD mice (N = 3) and in 289±25 POMC neurons from HFD mice (N = 4). VMH = Ventromedial hypothalamic nucleus; DMH = Dorsomedial hypo...
<div><p>Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiome...
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose ...
The dopamine D2 receptor (D2R) plays a critical role in diverse neurophysiological functions. D2R kn...
<p>Top Row: <i>Pomc-EGFP</i> mice (6-10 wks of age) were given leptin (5 mg/kg, ip, 30 min). Shown i...
<p>C57Bl/6J mice were given diets for 10 weeks and injected with leptin (0.6 mg/kg, 30 minutes). A. ...
<p><b>A</b>. Staining for pSTAT3 in the mediobasal hypothalamus of mice on a low-fat diet given an i...
<p>(<b>A</b>) Food intake in chow fed f/f and KO mice after receiving a bolus injection of leptin (5...
<p>Immuno-EM for pSTAT3 (DAB) in a leptin-treated (4 mg/kg ip; 10 min) <i>Lepr<sup>db/db</sup></i>;<...
<p>CLSM showing pSTAT3 IR (red) and α-MSH IR (green) and DAPI (blue) in the arcuate nucleus of a lep...
<p>(A) Stat3 phosphorylation was markedly decreased in Arc sections of <i>Ugcg</i><sup>f/f//CamKCreE...
<p>(A) Representative images for western blot experiement on total (t-) and phosphorylated (p-) STAT...
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocort...
Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothala...
<p>Activation of STAT3 phosphorylation by leptin in dendrites of hypothalamic AgRP neurons by immuno...
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocort...
<div><p>Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiome...
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose ...
The dopamine D2 receptor (D2R) plays a critical role in diverse neurophysiological functions. D2R kn...
<p>Top Row: <i>Pomc-EGFP</i> mice (6-10 wks of age) were given leptin (5 mg/kg, ip, 30 min). Shown i...
<p>C57Bl/6J mice were given diets for 10 weeks and injected with leptin (0.6 mg/kg, 30 minutes). A. ...
<p><b>A</b>. Staining for pSTAT3 in the mediobasal hypothalamus of mice on a low-fat diet given an i...
<p>(<b>A</b>) Food intake in chow fed f/f and KO mice after receiving a bolus injection of leptin (5...
<p>Immuno-EM for pSTAT3 (DAB) in a leptin-treated (4 mg/kg ip; 10 min) <i>Lepr<sup>db/db</sup></i>;<...
<p>CLSM showing pSTAT3 IR (red) and α-MSH IR (green) and DAPI (blue) in the arcuate nucleus of a lep...
<p>(A) Stat3 phosphorylation was markedly decreased in Arc sections of <i>Ugcg</i><sup>f/f//CamKCreE...
<p>(A) Representative images for western blot experiement on total (t-) and phosphorylated (p-) STAT...
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocort...
Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothala...
<p>Activation of STAT3 phosphorylation by leptin in dendrites of hypothalamic AgRP neurons by immuno...
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocort...
<div><p>Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiome...
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose ...
The dopamine D2 receptor (D2R) plays a critical role in diverse neurophysiological functions. D2R kn...