APP-immunoreactivity (IR) in the WT mouse retina colocalises with with calretinin positive- and GABA positive-amacrine cells, as well as ganglion cells.

<p>Immunohistochemistry on a transverse retinal section from an adult WT mouse for (A) amacrine cells labelled with Calretinin, and (B) APP-IR, showing (C) colocalisation. Immunohistochemistry for (D) GABAergic amacrine labelled with an antibody against GABA and (E) APP-IR, showing (F) colocalisation. Immunohistochemistry for (G) ganglion cells labelled with an antibody against GFP to localise YFP positive cells in the thy1-HYFP mouse and (H) APP-IR, showing (I) colocalisation. Arrows indicate examples of colocalisation, while * indicates a calretinin positive cell not labelled for APP-IR. Inner nuclear layer (INL), inner plexiform layer (IPL) and ganglion cell layer (GCL). Scale, 50 microns.