Developmental arrest in embryos with damaged DNA.

<p>Embryos produced by injection of Epi-Ctrl, Vas-Ctrl, Epi-SCF and VAS-SCF were closely followed for four days in culture, and scored for their stage of development. (A) Diagram of the early (first cycle) stages of development that were scored. Quantitative data showing the developmental progress at 8 (B), 19 (C), 24 (D), and 48 (E) hrs after fertilization. Fertilization was achieved by ICSI with injections timed not to exceed 15 min per group. For explanation of developmental stages see text. The experiment was repeated twice with at least 45 embryos examined for each group. Error bars represent standard deviations.