Effect of NK-4 on brain soluble or insoluble Aβ_x-40 and Aβ_x-42 in Tg2576 mice.

<p>Brains from mice aged 12 months were homogenized and separated into soluble (c, d) and insoluble (a, b) fractions of Aβ, and assayed for hAβ_x-40 (a, c) and hAβ_x-42 (b, d), respectively. FA: SDS insoluble and formic acid soluble fractions of Aβ. SDS: SDS soluble fractions of Aβ. Correlations are shown between the plasma and brain levels of hAβ_x-40 (e) and hAβ_x-42 (f) in Tg2576 mice. Data are the mean ± SEM of hAβ_x-40 or hAβ_x-42 in each mouse in saline-treated Tg2576 controls (n = 10), a low dose NK-4 (100 µg/kg)-treated group (n = 9), and a high dose NK-4 (500 µg/kg)-treated group (n = 8). *P<0.05, **P<0.01 vs. saline-treated Tg2576 group.