Projections of coronal (upper row) and axial (middle row) slices onto the SPM template as well as maximum intensity projections (lower row) are shown.

<p>MNI coordinates are indicated in the left upper corners. Increasing significance (T score) is color-coded from dark red to light yellow as indicated by the bar in the center. Note that only the clusters marked with a red rectangle contain peak voxels, which remained significant after correction for multiple comparisons at the voxel level. For better visibility, all results (including those from exploratory analyses) are shown at a height threshold of 0.01 uncorrected. Cluster sizes were restricted to 20 contiguous voxels for ROI analyses or subjected to cluster level correction (p<0.05 corrected) for the whole brain analysis. A) Combined effect of long CAG & its interaction with age, ROI analysis (left) and whole-brain analysis (right) revealing one bilateral cluster reaching from the pallidum across parts of the ventral thalamus to the midbrain (corrected P value at the cluster level, 0.003). B) Main effect of the long CAG, ROI analysis. C) Interaction analysis of long CAG with age, ROI analysis.