Modeling the rescue from desensitization by Anti-Desensitizer (AD) protein.

<p><b>A</b>, Model network pathways of AD desensitization protection pathway (red network designates AD pathway). <b>B</b>, PKC Apl II translocation in response to 5×5 min application of 5HT with 15 min washes in between and KT5720 present throughout from Farah et al. (2009) (bars) and modeling output (line). <b>C</b>, Top panel represents S dynamics in response to experimental protocol from <b>B</b>. Black line represents the ratio of S_OFF and S_ON to total S and the red line the ratio of S_IN2 to total S, and green line represents the ratio of S_AD and S_ADON to total S. Bottom panel represents the amount of AD over time. <b>D</b>, PKC Apl II translocation in response to 90 min application of 5HT and KT5720 present throughout from Farah et al. (2009) (bars) and modeling output (line). <b>E</b>, Top panel represents S dynamics in response to experimental protocol from <b>D</b>. Line colours similar to in <b>C</b>.