Longitudinal changes of hippocampus subregional networks.

<p>(A–C): Greater decreases in aMCI group-1 compared with controls group-1 between baseline and follow up. Thresholds were set at <i>P</i><0.05, corrected by FDR. (D): Overlap regions from the conjunction analysis between the longitudinal changes of respective hippocampus subregional networks. Thresholds were set at <i>P</i><0.05, corrected by FDR; PCC: posterior cingulate gyrus (left); MFG: medial frontal gyrus/supplementary motor area/paracentral lobule (bilateral); INS: insula (left); CRECR1: cerebellum_Crus1 (left); (E): Correlative analysis: within the aMCI group-1, the greater decreased functional connectivity between hippocampal regions and left PCC (i.e. average the Z values of the target in all networks) were positively related to greater reductions of episodic memory (AVLT-delayed recall scores, Spearman rho = 0.451, <i>p</i> = 0.021, two-tailed). It should be noted that the raw scores of AVLT-delayed recall for each subject was transformed to z scores. (F): Mean Z values of all sub-networks associated with overlap regions regarding the classification of independent groups: cutoff of 0.46 with sensitivity is 83.3%, specificity is 91.7%) in distinguishing aMCI-converters from controls group-2, while cutoff of 0.46 with sensitivity is 83.3%, specificity is 83.3%) in distinguishing aMCI-converters from aMCI group-2. It should be noted that these three groups only recruited the baseline data.