Serum Abs induced with M2e-MAP K2 exhibit cross-reactivity.

<p>(<b>A</b>) M2e amino acid sequence comparison of influenza virus A/PR8, A/FM and B/Lee. (<b>B</b>) Serum Abs of BALB/c mice (n = 5 mice) immunized i.n. or s.c. with K2 peptide and adjuvants were tested in an ELISA for binding to MDCK cells infected with influenza virus A/PR8 (square), A/FM (diamond) and B/Lee (circle). (<b>C</b>) M2e amino acid sequence from the pandemic influenza strain A/Texas/2009. (<b>D</b>) Sera with anti-M2e Abs induced by i.n. or s.c. immunization with K2 peptide and adjuvants or adjuvants alone were tested for binding to a synthetic peptide corresponding to the A/Texas/2009 M2e sequence as depicted in (<b>C</b>).