The effects of METH and raclopride on the expression of the Bcl-2 family of proteins and cytochrome c.

<p>(A) Representative immunoblots. (B) Pretreatment with raclopride attenuated METH-induced decreases in Bcl-2 protein levels, and (C, D) increases in Bax and Bad expression. In contrast, raclopride was ineffective to block cytochrome c induction (E). Protein expression was normalized to α-Tubulin. Key to statistics: ** = p<0.01; *** = p<0.001, in comparison to the Saline group. # = p<0.05; ## = p<0.01; ### = p<0.001, in comparison to the Rac group. ! = p<0.05; !! = p<0.01; !!! = p<0.001, in comparison of METH group to the Rac+METH group.