IFN-mediated inhibition of gene expression in Th17 cells.

<p>(<b>A</b>) The expression of IL-17A mRNA in Th17 cells treated with IFNβ. Naive T cells were cultured under Th17 condition in the presence of IFNβ (500 U/ml) for 3 days, the expression level of IL-17 mRNA was measured by Quantitative RT-PCR. Values are normalized to their average beta-actin values, and are presented as relative expression units. Error bars indicate ± SD among duplicate samples from one experiment. (<b>B</b>) Quantitative RT-PCR of the expression of mRNA encoding RORγt in Th17 cells treated with IFNβ. Values are normalized to their average beta-actin values and are presented as relative expression units. Error bars indicate ± SD among duplicate samples from one experiment. Data are representative of three independent experiments with similar results.