The lungs of <i>Mtb</i>-infected guinea pigs show evidence of tissue hypoxia and VEGF expression.

<p>A. Hematoxylin-eosin stain of guinea pig lungs on Day 56 after aerosol infection revealing well-circumscribed granuloma primarily comprising lymphocytes and epithelioid histiocytes with central necrosis (2×), containing acid-fast bacilli (inset; 60×). B. VEGF staining within TB granulomas in the lungs of guinea pigs infected with <i>Mtb</i> CDC1551 on Day 56 post-infection (40×).