Evolutionary history of the <i>CYP1</i> family genes.

<p>The panel shows the presence of <i>CYP1</i>-like genes and <i>CYP1A</i>, <i>CYP1B</i>, <i>CYP1C</i>, <i>CYP1D</i>, <i>CYP1E</i> and <i>CYP1F</i> subfamily genes in various echinozoan, tunicate, and vertebrate classes. Suggested events of gene duplication and gene loss are shown by bullets. Ten <i>CYP1</i>-like genes have been identified in the genome of the sea urchin <i>S. purpuratus</i> and three <i>CYP1A</i>-like genes in the genome of the anole lizard. These genes have not been further studied. Genes within brackets indicate known or suspected absence in at least one species within the taxon (birds, mammals). Data were collected from Godard et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Godard1" target="_blank">[29]</a>, Goldstone et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Goldstone3" target="_blank">[25]</a>, Jönsson et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Jnsson2" target="_blank">[7]</a>, Goldstone et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Goldstone1" target="_blank">[13]</a>, Gao et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Gao1" target="_blank">[35]</a>, Jönsson et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Jnsson1" target="_blank">[6]</a>, and the anole lizard genome database (<a href="http://www.ensembl.org/Anolis_carolinensis/Info/Index" target="_blank">http://www.ensembl.org/Anolis_carolinensis/Info/Index</a>). Footnote: ¹<i>CYP1D1</i> is a pseudogene in human, is expressed in macaques <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Uno1" target="_blank">[12]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028257#pone.0028257-Goldstone1" target="_blank">[13]</a>, and appears to be absent in the mouse.