Intrathecal synthesis of anti-tau antibodies.

<p>The intrathecally synthesized anti-tau IgG antibodies were significantly higher in the MS group as a whole than those in the controls (p<0.0001). There were significant differences in intrathecal synthesis of anti-tau antibodies between CIS, RR-rMS, RR-aMS or SP forms of MS and the control group (CIS vs. controls: p<0.01; RR-rMS vs. controls: p<0.005; RR-aMS vs. controls: p<0.05; SPMS vs. controls: p<0.005). Abbreviations: MS = multiple sclerosis; CIS = clinically isolated syndrome; RR-a = relapsing-remitting form during attack; RR-r = relapsing-remitting form during remission; SP = secondary progressive form; PP = primary progressive form; Ig = immunoglobulin.