Result of interval mapping scans by MapManager QTXb in F₂ rats.

<p>Analyses of linkage of aganglionosis severity in F₂ populations to chromosomal loci were performed using the MapManager QTXb20 software. Recombination frequencies (%) were converted into genetic distance (centiMorgan; cM) using the Kosambi map function, in which linkage data are provided as likelihood ratio statistic (LRS) scores. Genome-wide significance thresholds were calculated in terms of LRS by carrying out permutation tests for 500 permutations. The thresholds for suggestive (Su), significant (Si) linkages are indicated in dotted and thin lines, respectively. LRS, likelihood ratio statistic.