Hypothyroidism in Dicer cKO mice.

<p>(A) One month old cKO mice are smaller than Ctr littermates. (B) Body weight of male and female mice at one month after birth (n = 12 for each sex and genotype). P-value (***:p<10e-11) was calculated with Student's t-test comparing both Ctr and Het to cKO mice of the same sex. (C) ELISA assay of TSH serum level of Ctr (n = 10), Het (n = 10) and (n = 20) cKO mice at one month after birth (the same number of female and male mice have been analyzed). P-value (***:p<10e-13) was calculated with Student's t-test comparing both Ctr and Het to cKO mice. (D) Survival rates for Ctr, Het and cKO mice (n = 15 for each) during 12 weeks after birth. In all panels Ctr denotes Dcr1^Flox/Flox mice, used as controls.