<p>RPE damage was scored in wild-type and <i>C1qtnf5</i> Ser163Arg knock-in (KI) mice at ages between 6 and 24 months old and no signficant difference was found between any of the genotypes (n (wt) = 6, n(het) = 15, n(mut) = 14). Overall, there is a signficant correlation of RPE damage with age (Pearson correlation n(wt,het,mut) = 35, p = 0.0026, r<sup>2</sup> = 0.244).</p
<p><b>A.</b> H&E-stained sagittal sections of retinas from mice representing each indicated genotype...
<p>(A, B) To determine if the Akita mutation leads to RGC loss in DBA/2J mice, retinas from 8.5 mont...
Mutations in the ubiquitously expressed pre-mRNA processing factors 3, 8, and 31 (PRPF3, PRPF8, and ...
<p>A) Retinal sections from mice of the <i>C1qtnf5</i> wild-type, Ser163 Arg heterozygous (Het) and ...
<p>Light microscopic images of semi-thin sections of retinas from wild-type (wt/wt) and homozygous <...
The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age relate...
The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age relate...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cell...
<p>Mouse eyes were taken from 18–24 months old mice and processed for H-E staining. A–C, representat...
<p>(A) Representative dark-adapted ERG tracings show reduced a- and b-waves in response to a series ...
The retinal pigment epithelium (RPE) is a pigmented monolayer of cells lying between the photorecept...
The increasing popularity of the Cre/loxP recombination system has led to the generation of numerous...
<p>17-month-old C57BL/6 WT mice and Cxcr5 KO mice were used. (<b>A and B</b>) Representative toludin...
<p>(A) Fundus photographs at P21 indicate atypical RPE characteristic of the grainy retinal appearan...
<p><b>A.</b> H&E-stained sagittal sections of retinas from mice representing each indicated genotype...
<p>(A, B) To determine if the Akita mutation leads to RGC loss in DBA/2J mice, retinas from 8.5 mont...
Mutations in the ubiquitously expressed pre-mRNA processing factors 3, 8, and 31 (PRPF3, PRPF8, and ...
<p>A) Retinal sections from mice of the <i>C1qtnf5</i> wild-type, Ser163 Arg heterozygous (Het) and ...
<p>Light microscopic images of semi-thin sections of retinas from wild-type (wt/wt) and homozygous <...
The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age relate...
The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age relate...
<p>H&E stained cross-sections show that the RPE membrane (arrows) is broken and the retina is thicke...
The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cell...
<p>Mouse eyes were taken from 18–24 months old mice and processed for H-E staining. A–C, representat...
<p>(A) Representative dark-adapted ERG tracings show reduced a- and b-waves in response to a series ...
The retinal pigment epithelium (RPE) is a pigmented monolayer of cells lying between the photorecept...
The increasing popularity of the Cre/loxP recombination system has led to the generation of numerous...
<p>17-month-old C57BL/6 WT mice and Cxcr5 KO mice were used. (<b>A and B</b>) Representative toludin...
<p>(A) Fundus photographs at P21 indicate atypical RPE characteristic of the grainy retinal appearan...
<p><b>A.</b> H&E-stained sagittal sections of retinas from mice representing each indicated genotype...
<p>(A, B) To determine if the Akita mutation leads to RGC loss in DBA/2J mice, retinas from 8.5 mont...
Mutations in the ubiquitously expressed pre-mRNA processing factors 3, 8, and 31 (PRPF3, PRPF8, and ...