Determinants of maximal inhibitory factor, I_max.

<p>(A) Box-and-whisker plots of <i>S</i>-warfarin plasma concentration and INR on days 7/8/9 segregated by <i>VKORC1</i> -1639G>A genotype. Box-and-whisker plots representing <i>VKORC1</i> gene-dose effect during initiation. The top and bottom of the boxes represents 25^th and 75^th percentile, respectively; median is represented by the middle line, whiskers are the 95% CI, and outliers are identified as closed circles. (B) Warfarin daily dose on days 7/8/9 with respect to <i>VKORC1</i> genotype. (C) Frequency distribution of estimated I_max, shown as percent of total patients for each bin. (D) Association between <i>VKORC1</i> genotype and I_max. Results are represented as mean with standard deviation. (E) Additive effect of indication for warfarin therapy and <i>VKORC1</i> genotype on I_max. (F) INR time course for patients with AF and VTE over the initial 10 days of therapy with common genetics-guided dosing protocol. Results are represented as mean with 95% CI of the standard error. AF, atrial fibrillation; INR, international normalized ratio; VTE, venous thromboembolism. ^* P<0.05, ^** P<0.01, ^*** P<0.001, ^**** P<0.0001.