MLN4924 induces RA sensitization by inducing apoptosis.

<p>Cells were treated with DMSO control, RA (1.5 µM), MLN4924 (0.1 µM for HL-60, 1.0 µM for KG-1) alone or in combination for 24 hrs (HL-60) or 36 hrs (KG-1), followed by FACS analysis for apoptotic sub-G1 population. *, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.0001, compared to control (<b>A</b>). Cells were treated with indicated drugs at concentrations described above for 24 hrs, followed by DNA fragmentation assay (<b>B</b>) or immunoblotting using indicated antibodies (<b>C</b>).