FRC-mediated inhibition of IFNγ producing CD4+ and CD8+ T cells but not Th2 cells.

<p>(<b>a</b>) Percentage of blasting IFN<b>γ</b>^−/−OTI T cells cultured with peptide-loaded BMDCs and various concentrations of FRC.5 cells with or without exogenous IFN<b>γ</b>. (<b>b</b>) Dilution profiles of SE-eFluor670-labeled Th1 or Th2 skewed OTII cells when cultured with peptide-bearing BMDCs in the presence or absence of FRC.5 cells. (<b>c</b>) Quantification of SE-eFluor670 MFI (from (b)) as an index of proliferation (higher MFI represents reduced proliferation.) All experiments are representative of 2 similar trials. All conditions were assayed in triplicate.