Cellulose sulfate and PRO 2000 gels protect mice from genital herpes, but the response is modulated when virus is introduced in seminal plasma.

<p>(<b>A</b>). Survival curves for mice pretreated with a single dose of each blinded gel or no gel (untreated) and challenged with an LD90 of HSV-29G) diluted in PBS. Survival curves for mice pretreated with a single dose of DE-021 (HEC), DE-018 (CS) or DE-020 (PRO 2000) and challenged with an LD90 of HSV-2(4674) diluted in PBS (<b>B</b>) or pooled human seminal plasma (<b>C</b>). Data were obtained from 2 independent experiments (10 mice per group). The asterisk denotes significant protection relative to HEC-treated mice (p<0.001 for virus introduced in PBS and p = 0.015 for virus introduced in seminal plasma).