The special peptide alleviates Aβ aggregation and toxic effects <i>in vitro</i>.

<p>(A) Electron microscopic analysis of morphological change showing the effect of the special peptide or selected phage on Aβ_1-42 aggregation. Aβ_1-42 (a) or Aβ_1-10 (c) alone was incubated for 7 days; Aβ_1-42 with special peptide (b) or the selected phage (d) was incubated for 7 days; (B) Different concentrations of aggregated Aβ_1-42 were tested to assess its effect on neuronal cell viability by CCK-8 assay. *<i>P</i><0.05 when compared with the control group; (C) Cell viability was assessed in the presence of 20 µM Aβ_1-42 and different concentrations of the special peptide by CCK-8 assay. *<i>P</i><0.05 when compared with the control group. ^#<i>P</i><0.05 when compared with the group treated with 20 µM Aβ_1-42 only (note: 0.04 µg/µl peptide equal to 20 µM); (D) Detection of apoptosis in PC12 cells by PI staining. *<i>P</i><0.01 when compared with the control group. <i>^#P</i><0.01 when compared with the group treated with 20 µM Aβ_1-42 only.