TLR-2-deficient animals induce reduced levels of protective immune responses.

<p>For <i>in vivo</i> experiments, wild type and TLR-2^-/- mice were infected with H37Rv for 30 days, and subsequently treated with antibiotics for 4 weeks as described in the <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002378#s4" target="_blank">materials and methods</a>. Mice were then re-challenged with H37Rv. Groups of animals were sacrificed for the following studies. (<b>A</b>) CFU in lung homogenates of mice re-challenged with H37Rv. (<b>B</b>) Intracellular cytokines in CD4⁺ T lymphocytes derived from the lung. Results presented here are representative of three independent experiments.