Autoimmune gastritis does not develop in the absence of gastric H/Kα or H/Kβ.

<p>Gastric pathology in (A) H/Kα^−/− mice received either H/Kα^−/− CD4⁺ T cells or no inoculum (−) (B) H/Kβ^−/− mice received either H/Kα^−/− CD4⁺ T cells or no inoculum (−) (C) WT mice received H/Kα^−/− CD4⁺ T cells. Images representative of results of at least 9 mice in each group are shown. (D) Serum samples were collected from H/Kα^−/−, H/Kβ^−/− or WT mice that received CD4⁺ T cells from H/Kα^−/− mice. H⁺/K⁺ ATPase-specific autoantibodies in serum were detected by ELISA using serial 2-fold dilutions of mouse sera, with a starting dilution factor of 50. Data pooled from four independent experiments. Error bars, standard error.