<p>The experimental animal groups are as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026394#s4" target="_blank">methods</a> (n = 4/group). The top panel shows a representative immunoblot for PI3-kinase that was reprobed for α-tubulin as a loading control. The histogram in the bottom panel shows the densitometric measurements of the PI3-kinase signals on the immunoblot, relative to control. Values are the mean ± SEM.</p
<p>The level of Tubulin in each sample is detected as an internal control. One representative of thr...
<p>(A) Brains of 7-month-old female mice harboring aPKCλ flox/−; S1-cre (S1-cko) or flox/+ (Cont) we...
<p>A: Western blot analysis of σ<sub>1</sub>R and β-tubulin (as a loading control) proteins in the C...
<p>The experimental animal groups are as described in the <a href="http://www.plosone.org/article/in...
<p>Crude hippocampal extracts (5–15 μg/lane) were analyzed by Western blots developed with antibodie...
<p>Phosphorylated and total ERK1/2 levels in the striatum were measured by Western blot analysis. (A...
<p>(A) Representative Western blots of forebrain homogenate from control and Ptpn11<sup>D61Y</sup> m...
<p><b>A</b>, Immunoblotting analysis of molecules associated with PI3K/AKT signal pathway. β-actin w...
<p>(A) Each lane corresponds to the data from one mouse. (B) Relative band intensities from western ...
<p>Adult male C57BL/6 mice were pretreated with vehicle (5% DMSO) or H-89 (20 mg/kg, i.p.) for 30 mi...
<p>(<b>A</b>) Western blots using hippocampal lysates against p-MEK/MEK and p-ERK/ERK. After p-MEK w...
<p>(<b>A</b>) Representative western blots showing GSK3β, phosphorylated GSK-3 (pSer9-GSK3β), AKT, p...
<p>The upper side of panel (A) shows a representative Western blot for Phospho-p44/42 MAPK (Erk1/2) ...
<p>(A) Western blots of the brain homogenates developed with antibodies indicated at the left side o...
<p><b>A.</b> Representative immunoblot showing p-S505AKT and AKT in control (<i>elav-Gal4</i>), PI3K...
<p>The level of Tubulin in each sample is detected as an internal control. One representative of thr...
<p>(A) Brains of 7-month-old female mice harboring aPKCλ flox/−; S1-cre (S1-cko) or flox/+ (Cont) we...
<p>A: Western blot analysis of σ<sub>1</sub>R and β-tubulin (as a loading control) proteins in the C...
<p>The experimental animal groups are as described in the <a href="http://www.plosone.org/article/in...
<p>Crude hippocampal extracts (5–15 μg/lane) were analyzed by Western blots developed with antibodie...
<p>Phosphorylated and total ERK1/2 levels in the striatum were measured by Western blot analysis. (A...
<p>(A) Representative Western blots of forebrain homogenate from control and Ptpn11<sup>D61Y</sup> m...
<p><b>A</b>, Immunoblotting analysis of molecules associated with PI3K/AKT signal pathway. β-actin w...
<p>(A) Each lane corresponds to the data from one mouse. (B) Relative band intensities from western ...
<p>Adult male C57BL/6 mice were pretreated with vehicle (5% DMSO) or H-89 (20 mg/kg, i.p.) for 30 mi...
<p>(<b>A</b>) Western blots using hippocampal lysates against p-MEK/MEK and p-ERK/ERK. After p-MEK w...
<p>(<b>A</b>) Representative western blots showing GSK3β, phosphorylated GSK-3 (pSer9-GSK3β), AKT, p...
<p>The upper side of panel (A) shows a representative Western blot for Phospho-p44/42 MAPK (Erk1/2) ...
<p>(A) Western blots of the brain homogenates developed with antibodies indicated at the left side o...
<p><b>A.</b> Representative immunoblot showing p-S505AKT and AKT in control (<i>elav-Gal4</i>), PI3K...
<p>The level of Tubulin in each sample is detected as an internal control. One representative of thr...
<p>(A) Brains of 7-month-old female mice harboring aPKCλ flox/−; S1-cre (S1-cko) or flox/+ (Cont) we...
<p>A: Western blot analysis of σ<sub>1</sub>R and β-tubulin (as a loading control) proteins in the C...