The growth rates for beta cell mass and total body weight exhibit different dynamic trends based upon age.

<p>The age-associated changes in total beta cell mass (dotted line) corresponds to the product of the dynamic trends in beta cell density <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026873#pone.0026873-Gepts1" target="_blank">[11]</a> and volume of the pancreas <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026873#pone.0026873-Gepts1" target="_blank">[11]</a>. The change in body weight (solid line) as a function of age is an average value from male and female growth charts <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026873#pone.0026873-Kuczmarski1" target="_blank">[20]</a>. A similar figure appears in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026873#pone.0026873-Klinke1" target="_blank">[13]</a> but is included here for continuity.