β-AR blockers attenuated cardiac hypertrophy and improved the function of failing hearts

<p>. (A) to (C) showed β-AR blockers attenuated cardiac hypertrophy in rats induced by abdominal aortic constriction (AAC). (A) Representative images of hearts. Scale, 5 mm. (B) Ratio of heart weight to body weight. *P<0.05 vs. sham. (C) HE staining of rat hearts and cardiomyocyte cross-sectional diameter (µm). Scale bar, 50 µm. *P<0.05 vs. sham, #P<0.05 vs. AAC. (D) and (E) showed β-AR blocker attenuated Iso-induced cardiac hypertrophy in rats. (D) Ratio of heart weight to body weight. *P<0.05 vs. control. (E) HE staining of rat hearts and cardiomyocyte cross-sectional diameter (µm). Scale bar, 50 µm. Iso, isoproterenol. *P<0.05 vs. control, #P<0.05 vs. Iso.