MDM2-mediated degradation of p53 mutants.

Mdm2: keeping p53 under control

Piette, J.
Neel, H.
Marechal, V.

January 1997

The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially...

Ubiquitination and Degradation of Mutant p53

Lukashchuk, N
Vousden, KH

January 2007

While wild-type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilized and a...

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53

Xirodimas, Dimitris
Stephen, Charles W.
Lane, David

October 2001

The product of the Mdm2 oncogene directly interacts with p53 and promotes its ubiquitination and pro...

MDM2-C has p53-independent transformation activity.

Danielle R. Okoro (469827)
Nicoleta Arva (469828)
Chong Gao (53884)
Alla Polotskaia (469829)
Cindy Puente (469830)
Melissa Rosso (469832)
Jill Bargonetti (469834)

October 2013

<div>A. Analysis of exogenously expressed MDM2-FL or MDM2-C in H1299 cells with simultaneo...

p53 causes rapid SHP protein degradation independent of Mdm2.

Zhihong Yang (118036)
Yuxia Zhang (318750)
Jongsook Kim Kemper (318752)
Li Wang (15202)

February 2013

A: Western blots to determine the effects of p53 and Mdm2 on SHP protein expression in p53<sup...

MDM2 (C464A) dramatically inhibits p53 Ser 46 phosphorylation.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) H1299 cells were transfected with Myc-p53, HA-Axin or HA-MDM2 (C464A) as indicated, and analy...

SHP destabilizes p53 protein by enhancing the activity of Mdm2.

Zhihong Yang (118036)
Yuxia Zhang (318750)
Jongsook Kim Kemper (318752)
Li Wang (15202)

February 2013

A: Western blots. Plasmids expressing Flag-p53 were co-transfected with Flag-SHP plasmids in 293T...

Transactivation activity of p53 mutants.

Xavier Bernard (341031)
Philip Robinson (17437)
Yves Nominé (198521)
Murielle Masson (198518)
Sebastian Charbonnier (341032)
Juan Ramon Ramirez-Ramos (341033)
Francois Deryckere (341034)
Gilles Travé (198525)
Georges Orfanoudakis (341035)

February 2013

(A) H1299 cells were co-transfected by vectors coding for p53 proteins and a vector expressing th...

Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation.

Yap, DB
Hsieh, JK
Lu, X

November 2000

The ability of Mdm2 to inhibit the activities of a C-terminal truncated p53 mutant, p53-Delta30, whi...

High expression of endogenous MDM2-C protein in G/G mdm2 SNP309 MDM2 over-expressing cells.

Danielle R. Okoro (469827)
Nicoleta Arva (469828)
Chong Gao (53884)
Alla Polotskaia (469829)
Cindy Puente (469830)
Melissa Rosso (469832)
Jill Bargonetti (469834)

October 2013

<div>A. Western blot analysis of whole cell extracts from: MANCA, SJSA-1, ML-1 and K562 ce...

Nuclear import of p53 in relation to MDM2-mediated degradation and ubiquitination

Li Hui-ping
Zhang Yan-ping

January 2005

To study the function of p53 nuclear import in murine double minute 2 (MDM2)-mediated ubiquitination...

Both MDM2 and MDM2 (C464A) disrupt Axin-p53 interaction by recruiting p53.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) HEK 293T cells were transfected with 2 µg untagged Axin and increasing amounts (3 µg and 8 µg...

MDC1 and p53 interact following DNA damage through the tBRCT domain of MDC1.

Or David Shahar (475848)
Ronen Gabizon (160721)
Oren Feine (262525)
Raphael Alhadeff (196079)
Assaf Ganoth (196074)
Liron Argaman (475849)
Elee Shimshoni (475850)
Assaf Friedler (160766)
Michal Goldberg (252099)

October 2013

(a) A scheme of the different domains of p53. (b) A scheme of the different domains of MDC1. Note...

Up-regulation of MDM2 is the major inhibitor mechanism of p53 apoptotic transcription in hypoxia.

Lavinia Nardinocchi (358820)
Rosa Puca (125931)
Ada Sacchi (85367)
Gideon Rechavi (7479)
David Givol (358830)
Gabriella D'Orazi (358833)

February 2013

(A) Total mRNAs were reverse transcribed from RKO and A549 cell treated with cobalt or 2% O2...

MDM2 and its E3-inactivated mutant MDM2(C464A) show the similar effect on inhibition of Axin-induced p53 transcriptional activity.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) HEK 293 cells were transfected with p53-Luc reporter, HA-Axin, Myc tagged MDM2 and its mutant...

Mdm2: keeping p53 under control

Piette, J.
Neel, H.
Marechal, V.

January 1997

The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially...

Ubiquitination and Degradation of Mutant p53

Lukashchuk, N
Vousden, KH

January 2007

While wild-type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilized and a...

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53

Xirodimas, Dimitris
Stephen, Charles W.
Lane, David

October 2001

The product of the Mdm2 oncogene directly interacts with p53 and promotes its ubiquitination and pro...

MDM2-C has p53-independent transformation activity.

Danielle R. Okoro (469827)
Nicoleta Arva (469828)
Chong Gao (53884)
Alla Polotskaia (469829)
Cindy Puente (469830)
Melissa Rosso (469832)
Jill Bargonetti (469834)

October 2013

<div>A. Analysis of exogenously expressed MDM2-FL or MDM2-C in H1299 cells with simultaneo...

p53 causes rapid SHP protein degradation independent of Mdm2.

Zhihong Yang (118036)
Yuxia Zhang (318750)
Jongsook Kim Kemper (318752)
Li Wang (15202)

February 2013

A: Western blots to determine the effects of p53 and Mdm2 on SHP protein expression in p53<sup...

MDM2 (C464A) dramatically inhibits p53 Ser 46 phosphorylation.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) H1299 cells were transfected with Myc-p53, HA-Axin or HA-MDM2 (C464A) as indicated, and analy...

SHP destabilizes p53 protein by enhancing the activity of Mdm2.

Zhihong Yang (118036)
Yuxia Zhang (318750)
Jongsook Kim Kemper (318752)
Li Wang (15202)

February 2013

A: Western blots. Plasmids expressing Flag-p53 were co-transfected with Flag-SHP plasmids in 293T...

Transactivation activity of p53 mutants.

Xavier Bernard (341031)
Philip Robinson (17437)
Yves Nominé (198521)
Murielle Masson (198518)
Sebastian Charbonnier (341032)
Juan Ramon Ramirez-Ramos (341033)
Francois Deryckere (341034)
Gilles Travé (198525)
Georges Orfanoudakis (341035)

February 2013

(A) H1299 cells were co-transfected by vectors coding for p53 proteins and a vector expressing th...

Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation.

Yap, DB
Hsieh, JK
Lu, X

November 2000

The ability of Mdm2 to inhibit the activities of a C-terminal truncated p53 mutant, p53-Delta30, whi...

High expression of endogenous MDM2-C protein in G/G mdm2 SNP309 MDM2 over-expressing cells.

Danielle R. Okoro (469827)
Nicoleta Arva (469828)
Chong Gao (53884)
Alla Polotskaia (469829)
Cindy Puente (469830)
Melissa Rosso (469832)
Jill Bargonetti (469834)

October 2013

<div>A. Western blot analysis of whole cell extracts from: MANCA, SJSA-1, ML-1 and K562 ce...

Nuclear import of p53 in relation to MDM2-mediated degradation and ubiquitination

Li Hui-ping
Zhang Yan-ping

January 2005

To study the function of p53 nuclear import in murine double minute 2 (MDM2)-mediated ubiquitination...

Both MDM2 and MDM2 (C464A) disrupt Axin-p53 interaction by recruiting p53.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) HEK 293T cells were transfected with 2 µg untagged Axin and increasing amounts (3 µg and 8 µg...

MDC1 and p53 interact following DNA damage through the tBRCT domain of MDC1.

Or David Shahar (475848)
Ronen Gabizon (160721)
Oren Feine (262525)
Raphael Alhadeff (196079)
Assaf Ganoth (196074)
Liron Argaman (475849)
Elee Shimshoni (475850)
Assaf Friedler (160766)
Michal Goldberg (252099)

October 2013

(a) A scheme of the different domains of p53. (b) A scheme of the different domains of MDC1. Note...

Up-regulation of MDM2 is the major inhibitor mechanism of p53 apoptotic transcription in hypoxia.

Lavinia Nardinocchi (358820)
Rosa Puca (125931)
Ada Sacchi (85367)
Gideon Rechavi (7479)
David Givol (358830)
Gabriella D'Orazi (358833)

February 2013

(A) Total mRNAs were reverse transcribed from RKO and A549 cell treated with cobalt or 2% O2...

MDM2 and its E3-inactivated mutant MDM2(C464A) show the similar effect on inhibition of Axin-induced p53 transcriptional activity.

Ying He (125930)
Guili Lian (427964)
Shuyong Lin (427965)
Zhiyun Ye (427966)
Qinxi Li (427967)

June 2013

(A) HEK 293 cells were transfected with p53-Luc reporter, HA-Axin, Myc tagged MDM2 and its mutant...

Mdm2: keeping p53 under control

Piette, J.
Neel, H.
Marechal, V.

January 1997

The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially...

Ubiquitination and Degradation of Mutant p53

Lukashchuk, N
Vousden, KH

January 2007

While wild-type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilized and a...

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53

Xirodimas, Dimitris
Stephen, Charles W.
Lane, David

October 2001

The product of the Mdm2 oncogene directly interacts with p53 and promotes its ubiquitination and pro...

MDM2-mediated degradation of p53 mutants.

Abstract

Extracted data

MDM2-mediated degradation of p53 mutants.

Abstract

Extracted data

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