Dendrogram of E2 structure clustering in HCV quasispecies derived from HCV-infected subjects.

<p>A. Analysis of the structural distance (RMSD) matrix of modelled E2 structures from HCV-infected subjects (n = 391) using the neighbour-joining algorithm showed a clustering of genotype 1 variants (boxed), with the exception of singular outlier structures (circled) and genotype 3a variants. B. Subtype 1a and 1b clustered separately but were structurally similar. E2 structures derived from patients infected with the same HCV subtype formed distinct clusters.