6MMPr treatment of mice did not improve survival and exacerbated weight loss during WNV infection.

<p>Adult, female C3H mice were treated with vehicle or 0.5 mg 6MMPr once daily for eight consecutive days (days 0 to 7 pi). Immediately after the first treatment, mice were inoculated SC in the left rear footpad with diluent alone (mock; n = 4 per group) or with 10³ PFU of WNV (n = 8 per group) and monitored daily for weight loss and clinical signs. (A) Survival data are shown. Viral infection was confirmed in all WNV-inoculated survivors by seroconversion to WNV. (B) The means ± standard deviations of percentage initial weight are shown. Significant <i>P</i> values between mock-inoculated, 6MMPr-treated mice and WNV-inoculated, 6MMPr-treated mice are indicated as follows: *, <i>P</i><0.05; **, <i>P</i><0.005.