Level of anti-staphylococcal IgG (A) and IgA (B) in rhesus macaques and human volunteers.

<p>Antibody levels are reflected by Median fluorescence intensity (MFI) value. Each symbol represents a single rhesus macaque or human. Blue squares represent healthy rhesus macaques and red diamonds represent healthy human volunteers. Median values are indicated by horizontal lines. Arrows indicate statistically significant differences in median values (Mann-Whitney <i>U</i> test). Anti-staphylcoccal IgG and IgA levels were significantly different between rhesus macaques and humans for 29 and 25 out of 40 antigens, respectively. CHIPS, chemotaxis inhibitory protein of <i>S. aureus</i>; Clf, clumping factor; Efb, extracellular fibrinogen-binding protein; ET, exfoliative toxin; Fnbp, fibronectin-binding protein; HlgB, γ hemolysin B; Isd, iron-responsive surface determinant; Luk, leukocidin; SasG, <i>S. aureus</i> surface protein G; SCIN, staphylococcal complement inhibitor; Sdr, serine-aspartate dipeptide repeat protein; SE, staphylococcal enterotoxin; SSL, staphylococcal superantigen-like protein; TSST-1, toxic shock syndrome toxin 1.