<p>Panel on left side shows immunoblot and on right side shows quantification of western blotting data collected from corneal tissues of day-10 and day-14. A significant decrease in expression of CD31 on day-10 (62%, p<0.05) and day-14 (66%, p<0.05) was detected in decorin-delivered corneas compared to control corneas suggesting that AAV5-mediated decorin gene therapy is efficient in decreasing CNV. β-actin was used to confirm equal loading of protein in each well and normalization of the data. dcn = decorin.</p
<p>VEGF expression (^) showed progressive increase in <i>Hevin<sup>-/-</sup></i> mouse from week 2 (...
Corneal fibrosis is 3rd leading cause of global blindness according to WHO report. At present, no a...
<p>Densitometric comparison detected 10<sup>8</sup>–10<sup>10</sup> copies of GFP gene in AAV5 GFP-t...
<p>Data was collected after day 5 (early), 10 (mid), and 14 (late) of VEGF implantation from the con...
<p>Lectin (A–F) and collagen type IV (G–L) immunostaining was carried out in corneal tissue sections...
<p>Rabbit eyes were imaged early (5 day, Panels A, B), mid (10 day, Panels C, D), and late (14 day, ...
<p>Real-time PCR was carried out in naive, control (no decorin-delivered) and decorin-delivered rabb...
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissu...
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissu...
<p>Optical coherence tomography was performed in live rabbits on day 10 after the AAV5-gfp or AAV5-d...
<p>The delivered transgene expression first detected at 3-day, peaked at 7-day and maintained up to ...
<p>Photos taken at 1, 2, and 4 weeks after the induction of corneal NV in no treatment group and 1, ...
PURPOSE. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivere...
<p>No significant difference in the CD11b+ cells in tissue sections of rabbit corneas transfected wi...
Untargeted and uncontrolled gene delivery is a major cause of gene therapy failure. This study aimed...
<p>VEGF expression (^) showed progressive increase in <i>Hevin<sup>-/-</sup></i> mouse from week 2 (...
Corneal fibrosis is 3rd leading cause of global blindness according to WHO report. At present, no a...
<p>Densitometric comparison detected 10<sup>8</sup>–10<sup>10</sup> copies of GFP gene in AAV5 GFP-t...
<p>Data was collected after day 5 (early), 10 (mid), and 14 (late) of VEGF implantation from the con...
<p>Lectin (A–F) and collagen type IV (G–L) immunostaining was carried out in corneal tissue sections...
<p>Rabbit eyes were imaged early (5 day, Panels A, B), mid (10 day, Panels C, D), and late (14 day, ...
<p>Real-time PCR was carried out in naive, control (no decorin-delivered) and decorin-delivered rabb...
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissu...
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissu...
<p>Optical coherence tomography was performed in live rabbits on day 10 after the AAV5-gfp or AAV5-d...
<p>The delivered transgene expression first detected at 3-day, peaked at 7-day and maintained up to ...
<p>Photos taken at 1, 2, and 4 weeks after the induction of corneal NV in no treatment group and 1, ...
PURPOSE. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivere...
<p>No significant difference in the CD11b+ cells in tissue sections of rabbit corneas transfected wi...
Untargeted and uncontrolled gene delivery is a major cause of gene therapy failure. This study aimed...
<p>VEGF expression (^) showed progressive increase in <i>Hevin<sup>-/-</sup></i> mouse from week 2 (...
Corneal fibrosis is 3rd leading cause of global blindness according to WHO report. At present, no a...
<p>Densitometric comparison detected 10<sup>8</sup>–10<sup>10</sup> copies of GFP gene in AAV5 GFP-t...