Mdr2^−/−IKK2^Hep-KO mice show impaired growth and signs of jaundice.

<p>(A) Immunoblot of whole liver lysates from 3 representative mice for each depicted genotype. Tubulin serves as loading control. (B) Weight curve of male mice for the denoted genotypes. * p<0,05 for Mdr2^+/− IKK2^Hep-KO vs. Mdr2^−/−, ** p<0,001 for Mdr2^−/− IKK2^Hep-KO vs. Mdr2^−/−. (C) Macroscopic appearance of littermate male mice at 12 weeks of age. Genotypes as specified in the picture. (D) Necropsy of littermate mice from (C). White arrowheads: enlarged gall bladder in double knockout mouse. Black arrowhead: jaundiced peritoneal serosa in double knockout mouse vs. normal appearance of serosa in Mdr2^−/− and Mdr2^+/−IKK2^Hep-KO mice. The ruler indicates centimeters in C and D.