Significant and suggestive QTL for plasma esterified and free cholesterol in F₂ mice derived from B6.apoE^−/− and C3H.apoE^−/− mice.

a<p>From Mouse Genome Informatics database at <a href="http://www.informatics.jax.org" target="_blank">http://www.informatics.jax.org</a>.</p>b<p>Suggestive QTL and significant QTL were 2.4 and 3.4, respectively, for free cholesterol and 2.4 and 3.3, respectively, for esterified cholesterol as defined by 1000 permutation tests.</p>c<p>Support intervals (SI) were defined by a 1-unit decrease in LOD score on either side of the peak marker.</p>d<p>Variance (%) indicates the percentage of the phenotypic variance at the peak marker.</p>e<p><i>P</i>_emp, empirically determined <i>P</i>-value for the whole genome, was calculated using the permutation test function of MapManager QTXb20.</p>f<p>Model of inheritance was determined using the MapManager QT program. C3H was the high allele at all the markers, contributing to elevated free or esterified cholesterol levels.